59-01-8

  • Product Name:Kanamycin
  • Molecular Formula:C18H36 N4 O11
  • Purity:99%
  • Molecular Weight:484.504
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Product Details;

CasNo: 59-01-8

Molecular Formula: C18H36 N4 O11

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What is the KANAMYCIN ?

KANAMYCIN is , while it's Molecular Formula is C18H36 N4 O11. Kanamycin A is an antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.

What is the CAS number for KANAMYCIN ?

The CAS number of KANAMYCIN is 59-01-8.

More information of KANAMYCIN 59-01-8 are:

Synonyms

KanamycinA (7CI);4,6-Diamino-2-hydroxy-1,3-cyclohexane 3,6'-diamino-3,6'-dideoxydi-a-D-glucoside;KM;Kanacin;Kanamycin;

CAS Number

59-01-8

Molecular Formula

C18H36 N4 O11

Molecular Weight

484.504

Density

1.62g/cm3

Boiling Point

809.5°Cat760mmHg

Flash Point

443.4°C

PSA

282.61000

LogP

-4.49020

Pka

pKa 6.40/7.55/8.40/9.40(H2O) (Uncertain)

What is KANAMYCIN (59-01-8) used for?

Kanamycin is a well-known bactericidal antibiotic. It belongs to the aminoglycoside antibiotic group. It can be used for the treatment of various pathogens including E. coli, Proteus species (both indole-positive and indole-negative), Enterobacter aerogenes, Klebsiella pneumoniae, Serratia marcescens and Acinetobacter species1-4. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate5. Aminoglycoside-type drug take actions through “irreversibly” binding to the 30S subunit of the ribosome, further blocking the protein synthesis. Kanamycin kills bacteria cells binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes5.

InChI:InChI=1/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1

Articles related to KANAMYCIN:

Article

Source

Synthesis of ring II/III fragment of Kanamycin: A new minimum structural motif for aminoglycoside recognition

Zárate, Sandra G.,Bastida, Agatha,Santana, Andrés G.,Revuelta, Julia

, (2019/08/20)

COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION

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Paragraph 00410; 00411, (2018/02/28)

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